sideremie g/dl

pierderi 1 - 3 - 5 mg CTLF 300 - 350 g/dl

sideremie

neoplasm

LED

medicamente: HIN, cloramfenicol, citostatice

intoxicatii: Pb, alcool

porfirii

clinic

semne de hemocromatoza

diagnostic

mo

sideroblasti inelari

sp

eritrocite dimorfe

tratament

B₆

transfuzie

anabolizante

kelatori fier

factori de crestere

infectii cronice: TBC, abces pulmonar, endocardita bacteriana, pielonefrita cronica, osteomielita

boli autoimune: PR, LES, B Crohn

neoplasm nonhematologic

carentiale, prin deficit de:

vit B₁₂

acid folic

noncarentiale

sindrom mielodisplazic

eritroleucemie

insuficienta hepatica

icter obstructiv

mixedem

alcoolism

intarzierea sintezei ADN ( faza S)

discrepanta nucleocitoplasmatica

asincronism de maturatie nucleocitoplasmatica

Anemia carentiala prin acid folic

nu este sintetizat in organism

se absoarbe in jejun

cedeaza grupari CH₃ homocisteinei, reactia exacerbata in prezenta B₁₂

intervine in formarea timinei ce contribuie la formarea ADN

N = 6 - 20 ng/ml

Anemia carentiala prin B₁₂

B₁₂ are 2 forme coenzimatice:

metilcobalamina

adenozilcobalamina

B₁₂ de origine exogena, se gaseste in preparate de carne.

se combina in stomac cu FI

se absoarbe in ileonul terminal

proteina de transport a B₁₂ = transcobalamina

nivel plasmatic B₁₂ 200 - 900 pg/ml

necesarul zilnic 1- 2 mg/zi